MANAGEMENT BOARD OF DIRECTORS S. COLIN NEILL President, CFO, Secretary and Treasurer ROBERT F. JOHNSTON Executive Chairman Founder and President, Johnston Associates Inc.   SRINIVAS AKKARAJU, M.D., Ph.D. Managing Director, New Leaf Venture Partners   ANTHONY B. EVNIN, Ph.D. General Partner, Venrock Associates   CHARLES W. NEWHALL, III Co-Founder and General Partner, New Enterprise Associates